Ingredient file // Vitamin or mineral
Menadione Sodium Bisulfite Complex
A measured vitamin K addition with limits
Menadione sodium bisulfite complex is a manufactured powder added through a vitamin premix. It supplies vitamin K activity for normal blood clotting. The amount in food is nutritional, and the ingredient offers no proven extra benefit for a healthy dog.
- What it is
- A powder containing a menadione bisulfite compound and extra bisulfite, used to add vitamin K activity.
- Made from
- Synthesized menadione and sodium bisulfite
- Main job
- Vitamin K for clotting
- Typical amount
- Usually 3 to 5 mg per kg of dry dog food
- Watch for
- It cannot treat rat poison exposure
- Not the same as
- Vitamin K1
Straight answer
Is Menadione Sodium Bisulfite Complex safe for dogs?
Read it as a small vitamin addition
Expect this name among the vitamins near the end of the list. Check the food's complete-and-balanced statement and judge its main ingredients separately. The complex has a practical nutritional job. Its presence gives no reason to expect stronger joints or protection after rat poison exposure.
- Why it is in the food
- Vitamin K for clotting
Our read // In our catalog
In 1 of every 14 foods we track
Share of foods that list it
7%
230 of the 3,205 foods with an ingredient list on file, from 17 brands. 177 dry dog food, 52 wet dog food, 1 dog food topper.
Each square is 1% of the catalog
Where it sits on the label
Median position 21. In the top five of 0 foods, so it is usually a minor ingredient.
Above the salt
Usually listed after the salt, which caps it at roughly 1% of the recipe in 95% of foods.
Price per lb
Median of the cheapest bag price across 146 priced foods, 26% below the catalog. The price is the food's, not the ingredient's.
Who leans on it
49%
of the foods that list it are from Purina. 17 brands use it in total.
What it is
How it is made
Feed-vitamin manufacturers synthesize menadione for animal diets. They combine it with bisulfite to make a powder suited to premixes. This is a manufactured feed additive, rather than a leftover from food processing.5,6,7
- 01 // Source Chemical starting material A common synthesis route starts with 2-methylnaphthalene, a chemical feedstock for menadione.
- 02 // Process Make menadione The starting material is oxidized to produce the menadione that supplies vitamin K activity.
- 03 // Process Add bisulfite Menadione is combined with sodium bisulfite; extra bisulfite helps stabilize the feed ingredient.
- 04 // Output Premix powder The powder is supplied to feed makers for measured addition through a vitamin premix.
What is in it
Composition, as fed
33
% menadione
The supplier's minimum assay for menadione in the powder as sold. This is a specification floor, not a measured batch average.
Each row gives one supplier's specification limit for powder as sold, not a measured range or dry matter result. Menadione is contained within the bisulfite compound, so these assays overlap and must not be added together.6
Why it is in the bag
What the manufacturer gets
-
01
Supplies vitamin K
Formulators add a measured source of vitamin K activity to support production of the blood-clotting proteins that depend on this nutrient.3,4
-
02
Fits a premix
The supplier sells the powder for premixes. Blending a small addition into a larger vitamin mix makes it practical to distribute through a batch of feed.6
-
03
Works at feed scale
Menadione is synthesized for commercial animal feed, giving manufacturers a standardized ingredient they can buy and measure across large production runs.5,6
How much An industry survey reported typical use of 3 to 5 mg of this complex per kg of dry dog food.3
Our read // The claims
What the evidence supports
Strong: controlled studies in dogs agree. Some: small or mixed dog data. Thin: mechanism or lab work only. None: nothing, or the evidence points the other way.
-
Brands say
Supplies vitamin K for normal blood clotting
Evidence
- Strong
- Some
- Thin
- None
FDA identifies 4 clotting proteins that require vitamin K, and an AAFCO panel judged this complex a suitable vitamin K source. That supports meeting a nutritional need; it does not show faster clotting in an adequately fed dog.3,4
-
Brands say
Strengthens a dog's bones and joints
Outruns the evidence
Evidence
- Strong
- Some
- Thin
- None
Vitamin K is involved in the bone protein osteocalcin, and a review describes bone findings in chickens. It cites no controlled dog trial showing that this complex strengthens bones or improves joints at food amounts.2,4
-
Critics say
Causes anemia at ordinary dog-food amounts
Outruns the evidence
Evidence
- Strong
- Some
- Thin
- None
An AAFCO review reports no adverse effects in 2 dogs given oral menadione for 73 days at a dose above nutritional use. That small, older study cannot show lifelong safety, but evidence of anemia at ordinary food amounts is lacking.3
-
Owners say
Protects a dog that ate rat poison
Outruns the evidence
Evidence
- Strong
- Some
- Thin
- None
In a 4-dog case series, veterinary treatment with vitamin K1 corrected clotting tests after anticoagulant rodenticide poisoning. Poison specialists explicitly reject menadione in food as a substitute. Other kinds of rat poison require different treatment.1,8,9
Straight answers
What owners ask
-
Q01
Is it just filler?
NoIt is added in milligrams to supply vitamin K activity, not to add bulk, protein or energy. A place near the end of the ingredient list is expected for this kind of vitamin addition.3,6
-
Q02
Is it the same as vitamin K1?
NoVitamin K1 is used to treat anticoagulant rodenticide poisoning. This ingredient supplies menadione activity in food. The forms share a nutritional role, but food containing the complex cannot replace veterinary treatment.4,8,9
-
Q03
Is it allowed in dog food?
Qualified useFDA acknowledges its use in pet food, while its published prior sanction specifically covers poultry feed. An AAFCO expert panel recommended its use in food for all animals under good manufacturing and feeding practices.3,4
Who uses it
Brands, best sellers and the company it keeps
Top brands, by foods that list it
Foods that list it / all the brand's recipes we track.
Plus 7 more brands.
Amazon best sellers that list it
- #2 Purina One SmartBlend Adult Dog Lamb & Rice Formula Dry Dog Food
- #3 Purina Pro Plan Adult Complete Essentials Shredded Blend Chicken & Rice Formula Dry Dog Food
- #9 Purina Pro Plan Adult Sensitive Skin & Stomach Salmon & Rice Formula Dry Dog Food
- #15 Purina One True Instinct with a Blend of Real Turkey & Venison Dry Dog Food
- #20 Purina Pro Plan Adult Small Breed Shredded Blend Chicken & Rice Formula Dry Dog Food
- #23 Purina Pro Plan Adult Sensitive Skin & Stomach Small Breed Formula Dry Dog Food
- #26 Purina Pro Plan Puppy Chicken & Rice Formula Dry Dog Food
- #28 Nature’s Recipe Grain-Free Easy to Digest Salmon, Sweet Potato, & Pumpkin Recipe Dry Dog Food
Rank on Amazon's dog food best seller list, checked October 2026.
Usually listed with, share of the foods that list it
- Mixed Tocopherols 55%
- Chicken 46%
- Natural Flavor 42%
- Beef Fat 40%
- Rice 40%
- Whole Grain Corn 33%
- Whole Grain Wheat 28%
- Soybean Meal 27%
- Chicken Meal 27%
- Barley 26%
- Salmon 22%
- Corn Protein Meal 20%
On the shelf
Foods that list Menadione Sodium Bisulfite Complex
230 foods in our catalog list it. These 60 list it highest on the label.
Dave's Pet FoodDave’s Pet Food Bland Diet Pouches Dave’s Bland Duck & Pumpkin Pouch Recipe for Dogs / 10 Pack - Pou Wet Dog Food
Royal CaninRoyal Canin Veterinary Selected Protein PW Moderate Calorie Grain-Free Dry Dog Food
Nature's RecipeNature’s Recipe Healthy Skin Vegetarian Recipe Dry Dog Food
Dave's Pet FoodDave’s Pet Food Dave’s Bland Beef & Rice Pouch Recipe for Dogs / 10 Pack - Pouche Wet Dog Food
Nature's RecipeNature’s Recipe Original Adult Chicken Meal & Rice Recipe Dry Dog Food
PurinaPurina Pro Plan Sport Puppy High Protein Beef & Rice Entrée Classic Wet Dog Food
Royal CaninRoyal Canin Veterinary Selected Protein PW Large Breed Grain-Free Dry Dog Food
Hill'sHill’s Adult Chicken & Barley Entrée Wet Dog Food
PurinaPurina Beyond Simply Farm-Raised Chicken & Whole Barley Recipe Dry Dog Food
PurinaPurina Beyond Simply Pasture-Raised Lamb & Whole Barley Recipe Dry Dog Food
Hill'sHill’s Hill’s Science Diet Adult Salmon & Barley Entrée Wet Dog Food
PurinaPurina Alpo Come & Get It! Cookout Classics Dry Dog Food Show 48 more
Nature's RecipeNature’s Recipe Easy to Digest Chicken Meal, Rice, & Barley Recipe Dry Dog Food
Nature's RecipeNature’s Recipe Original Small Bites Chicken Meal & Rice Recipe Dry Dog Food
Nature's RecipeNature’s Recipe Original Senior Lamb Meal & Rice Recipe Dry Dog Food
Royal CaninRoyal Canin Veterinary Selected Protein PW Grain-Free Dry Dog Food
Royal CaninRoyal Canin Veterinary Hydrolyzed Protein PS Grain-Free Dry Dog Food
Nature's RecipeNature’s Recipe Original Adult Lamb Meal & Rice Recipe Dry Dog Food
Royal CaninRoyal Canin Veterinary Skin Support Dry Dog Food
Natural BalanceNatural Balance L.I.D. Limited Ingredient Diets Grain-Free Salmon & Sweet Potato Dry Dog Food
PurinaPurina One SmartBlend Sensitive Systems Formula Adult Premium Dry Dog Food
PurinaPurina Pro Plan All Ages Sport Performance 30/20 Chicken & Rice Formula Dry Dog Food
PurinaPurina Pro Plan Adult Small Breed Chicken & Rice Formula Dry Dog Food
Hill'sHill’s Prescription Diet i/d Puppy Turkey Digestive Care Wet Dog Food
PurinaPurina ONE Skin and Coat Dry Dog Food
Hill'sHill’s Science Diet Puppy Small & Mini Beef & Barley Entrée Wet Dog Food
Hill'sHill’s Science Diet Adult Perfect Digestion Small & Mini Chicken & Vegetables Entrée Wet Dog Food
PurinaPurina Dog Chow High Protein Real Chicken Dry Dog Food
Royal CaninRoyal Canin Dalmatian Adult Dry Dog Food
PurinaPurina Dog Chow High Protein with Real Lamb Dry Dog Food
PurinaPurina Beyond Simply Small Dog White Meat Chicken & Egg Recipe Dry Dog Food
Nature's RecipeNature’s Recipe Grain-Free Easy to Digest Chicken, Sweet Potato, & Pumpkin Recipe Dry Dog Food
Natural BalanceNatural Balance L.I.D. Limited Ingredient Diets Grain-Free Salmon & Sweet Potato Small Breed Bites Dry Dog Food
PurinaPurina One True Instinct with a Blend of Real Turkey & Venison Dry Dog Food
PurinaPurina Pro Plan Adult Sensitive Skin & Stomach Large Breed Formula Dry Dog Food
Nature's RecipeNature’s Recipe Small Breed Grain-Free Easy to Digest Chicken, Sweet Potato, & Pumpkin Recipe Dry Dog Food
Hill'sHill’s Puppy Chicken & Barley Entrée Wet Dog Food
PurinaPurina Pro Plan Sensitive Skin & Stomach Salmon & Rice Entrée Classic Wet Dog Food
PurinaPurina One True Instinct High Protein with Real Chicken & Duck Dry Dog Food
PurinaPurina Dog Chow Natural Plus Vitamins & Minerals Dry Dog Food
MerrickMerrick Limited Ingredient Diet Grain-Free Real Salmon & Sweet Potato Recipe Dry Dog Food
MerrickMerrick Limited Ingredient Diet Grain-Free Real Lamb & Sweet Potato Recipe Dry Dog Food
MerrickMerrick Limited Ingredient Diet Grain-Free Real Chicken & Sweet Potato Recipe Dry Dog Food
PurinaPurina Pro Plan Adult Sensitive Skin & Stomach Salmon & Rice Formula Dry Dog Food
PurinaPurina Pro Plan Adult Sensitive Skin & Stomach Small Breed Formula Dry Dog Food
Nature's RecipeNature’s Recipe Grain-Free Easy to Digest Salmon, Sweet Potato, & Pumpkin Recipe Dry Dog Food
JinxJinx Grain-Free Beef Paté Wet Dog Food
JinxJinx Grain-Free Chicken Pâté Wet Dog Food
NutriSourceNutriSource Trout & Rice Wet Dog Food
PurinaPurina Pro Plan Sensitive Skin & Stomach Beef & Oat Meal Entrée Classic Wet Dog Food
PurinaPurina Pro Plan Puppy Sport 30/20 Chicken Dry Dog Food
Hill'sHill’s Science Diet Adult Sensitive Stomach & Skin Salmon & Brown Rice Recipe Dry Dog Food
Royal CaninRoyal Canin Veterinary Hepatic Dry Dog Food
PurinaPurina Pro Plan All Ages Sport Performance 30/20 Beef & Rice Formula Dry Dog Food
PurinaPurina Dog Chow Tender & Crunchy Dry Dog Food
PurinaPurina Dog Chow Complete Adult with Real Chicken Dry Dog Food
PurinaPurina Dog Chow Complete Adult with Real Beef Dry Dog Food
Nature's RecipeNature’s Recipe Large Breed Grain-Free Easy to Digest Chicken, Sweet Potato, & Pumpkin Recipe Dry Dog Food
Nature's RecipeNature’s Recipe Prime Blends Salmon, Barley & Chicken Recipe Dry Dog Food
Nature's RecipeNature’s Recipe Prime Blends Grain-Free Chicken, Turkey, and Butternut Squash Recipe Dry Dog Food Leaving it out
Foods without menadione
For owners who skip menadione: popular dry foods priced like the ones that list it ($1.68 to $3.36 per lb), with no menadione on the label.
BlueBlue Life Protection Formula Adult Chicken and Brown Rice Recipe Dry Dog Food
BlueBlue Life Protection Formula Adult Small Breed Chicken and Brown Rice Recipe Dry Dog Food
Hill'sHill’s Science Diet Adult Sensitive Stomach & Skin Chicken Recipe Dry Dog Food
Hill'sHill’s Science Diet Adult 1-6 Small Bites Chicken & Barley Recipe Dry Dog Food
Taste of the WildTaste of the Wild High Prairie Canine Recipe with Roasted Bison & Roasted Venison Grain-Free Dry Dog Food
Royal CaninRoyal Canin Small Adult Dry Dog Food
WellnessWellness Complete Health Deboned Chicken & Oatmeal Dry Dog Food
NutroNutro Natural Choice Adult Chicken & Brown Rice Recipe Dry Dog Food Checked against the ingredient list we store for each food. Labels change, so read the bag before you buy.
Sources
What we read
Checked October 1, 2026.
- 1 Intravenous vitamin K1 normalises prothrombin time in 1 hour in dogs with anticoagulant rodenticide toxicosis
- 2 Beyond the Coagulation Cascade: Vitamin K and Its Multifaceted Impact on Human and Domesticated Animal Health
- 3 Recommendations for Use of Menadione Sodium Bisulfite Complex (MSBC) in Animal Feed
- 4 Vitamin K Substances and Animal Feed
- 5 2024 Limited Scope Technical Evaluation Report: Vitamins, Livestock
- 6 MSBC Menadione Sodium Bisulfite Complex
- 7 Animal feed composition
- 8 Vitamin K Deficiency
- 9 Rodenticide Refresher for Veterinary Professionals